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From its use in topical treatment and from restricted knowledge from occupational research, resorcinol does not appear to be irritating to the skin within the concentrations reported. Van Leeuwen et al. There is not any indication as as to if the teratogenic results have been endocrine mediated or not EC, c. In humans, dermal exposure to resorcinol has been reported to be associated with thyroid effects, CNS disturbances, pink blood cell adjustments, and a low incidence of skin sensitization. Five of three.
The bulk of the urine-recovered dye should have been taken up into the attractive layer of the skin after which slowly launched into the circulation. A cumulative four-day absorption assuming cm 2 of scalp was given as 0.

Although thyroid effects are a significant finish-level in each human case-studies and animal research, there is a lack of consistency in the results in the animal studies. Resorcinol brought on no antagonistic effects in a number of replica and developmental toxicity studies in rats and rabbits. Resorcinol isn't considered to be genotoxic.
Other skin effects have been hyperplasia, hyperkeratosis, inflammation, and sebaceous gland hyperplasia, whereas there have been no systemic therapy-associated lesions. With resorcinol, several initiation—promotion studies with hamsters Maruyama et al. Female Syrian golden hamsters 10—20 per group were treated with two subcutaneous injections of. In a research performed by Hasegawa et al.
These figures agree nicely with the above exposure estimate based on the Yeung et al.







  • There were no printed animal studies displaying thyroidal results with a dose—response relationship that could be used for a tolerable intake.




  • Resorcinol brought on no opposed effects in a number of replica and developmental toxicity research in rats and rabbits.




  • As talked about in section 9.





In in vitro genotoxicity checks, resorcinol confirmed principally adverse results. Results from all reported in vivo checks for genotoxicity had been negative. Mostly negative outcomes had been reported within the initiation—promotion research carried out utilizing several species. UV irradiation triggered no elevated pores and skin reactions. The iodination course of is catalysed by a haem-containing enzyme.
In both species, there were no opposed effects on last imply physique weights, haematology, or scientific chemistry parameters, and no chemical-related gross or microscopic lesions had been noticed. In one other study, rats had been exposed to 0 or 0. No thyroid hormone measurements had been carried out.
The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and treated skin areas confirmed slight erythema and excessive dryness. Mean information for three donors and sixteen replicates point out a plateau in receptor fluid concentration between 24 and forty eight h, as reflected by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats strain not given;.
A concentration of zero. These substances had been found to be potent inhibitors of thyroid peroxidase or I organification. Resorcinol in addition to 2- and 5-methylresorcinol had been reported to be At an iodide focus of zero.
In one other research, male F rats had been treated with three intraperitoneal injections of three-methyl-. Based on the research of Yeung et al.


The tolerable intake of 0. It is subsequently attainable that these neurological effects are as a result of acute effect of the gavage administration. CNS results in people and animals have been related to acute publicity to resorcinol.

According to the results obtained, Daphnia magna is the most sensitive organism, and resorcinol can be classified as acutely poisonous only to Daphnia. However, this worth is questionable to be used as a limit worth in threat assessment this is the highest focus examined in this research , and the NOEC could possibly be significantly larger than acknowledged in the examine. In the atmosphere, resorcinol is rapidly degraded half-life about 2 h by reaction with photochemically produced hydroxyl radicals. Under aerobic conditions, resorcinol proved to be readily biodegradable in a check carried out in accordance with OECD TG C, and it is more likely to be biodegraded underneath anaerobic conditions.